An analyzer for analyzing a specimen includes a central control unit that instructs systems of the analyzer of a process operation; and a primary control unit that time-divisionally outputs an instruction by the central control unit. Core nanoparticles andor quantum dots containing one or more elements from group IB andor IIIA andor VIA may be coated with one or more layers containing elements group IB, IIIA or VIA. The film is sealingly fixed to the transparent substrate for preventing dusts from entering the light reflection pattern during the process of assembling the spread illuminating apparatus. The reader head is operable is operably engaged with and moveable along the reference element for measuring relative movement of the reader head along the reference element. Data indicating a selection of a particular interaction page is received. One aspect utilizes tracking near-resonance complex impedance for a quartz resonator based calorimeter sensor to derive ultra-sensitive temperature measurement from the sensor.