A method and apparatus for rotating a cross-sectional asymmetrical condition of a laminar flowing material is provided in a hot runner system for supplying a laminar flowing material. A waveguide may be provided for guiding high-frequency waves into the vacuum vessel, and a dielectric member may be arranged at an end portion of the waveguide. A panel of disorders can be analyzed at high speeds. The imaging element may be imaged and developed on-press and may be sprayed onto a hydrophilic surface to create a printing surface that may be processed wholly on-press. An activity input is provided to the computer program, the activity input including an intensity value representing the extent of change of the parameter. The invention encompasses the use of the interaction of RCC356 polypeptides and isovaleric acid as the basis of screening assays for agents that modulate the activity of the RCC356 receptor.