A system for managing event streams is provided that includes a volatile memory, a non-volatile memory, and a processor. A measured range it is adjusted to account for processes not included in the original measurements. A gate region and source and drain regions, which between them define a channel, are produced so that the gate region extends above the channel. This remote server has a virtual map of all the embedded devices on a computer that the person uses. The perfusion circuit defines a path for re-circulating a solution containing a macromolecular complex through a coronary circulation circuit through a subject’s heart during a surgical procedure in which the substance is prevented from being delivered to the subject’s other organs.