The disclosure provides for a biocompatible, thromboresistant coating including a chalcogenide compound that induces nitric oxide formation; and a biocompatible matrix incorporating the chalcogenide compound. The system comprising multiple modules capable of providing a style score, a punctuation score, a spelling score, a quotation score, an enrichment score, a syntax analysis score, a focus score, an idea score and a cohesion score. The compounds of the disclosure may be used for pathological neuronal exocytosis-mediated cosmetic andor therapeutic purposes. On the portable device, the method typically includes displaying questions and appropriate answer choices for a patient to select from. If the frame update of the desktop GUI should be performed without the one or more missing image blocks, the client device performs the frame update of the desktop GUI using the plurality of image blocks without using the one or more missing image blocks.