The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. In an embodiment of the invention, the caller calling in at such a peak time is notified of the relatively long wait time to speak to an agent. The matrix can be tailored to further comprise one or more bioactive agents. The digital certificate issuer issues digital certificates regarding the respective authorized users of the document management system. A pair of separate adhesive deposits are disposed on outer surfaces of the corners of the minor flaps that mate with the first major flap andor on an inner surface of complimentary corners of the first major flap. The pneumatic biasing arrangement is also configured, connected and operated to reduce the force which must be exerted by the driving and driven members in extending and retracting the linear actuator.