The present invention includes an apparatus that holds the probes to a solid support throughout the passages of the functionalization process, thus avoiding user-dependent breakage or damage of the fragile AFM cantilevers. Furthermore, the claimed method and system may allow for a tiered approach to a manufacturer switch by allowing a corporate entity or owner of a pharmacy network to designate a pharmacy wide preferred manufacturer while giving a local pharmacy the power to decide when to implement a switchover at a local level. After a defect region of the difference image is clearly defined, a simulation at the centroid of the defect region is performed. The holding unit holds a voltage applied to the mechanism in response to the detection signal and is capable of releasing the held voltage. A clutch is operable to selectively connect the output of the second gear set to the output shaft. The throttle-opening-degree control device decreases the degree of opening of the throttle valve only for a limited time when the negative pressure in the first pressure chamber is smaller than a predetermined necessary negative pressure determined by an operating-force relating amount related to the operating force applied to the brake operating member.