An exerciser machine including a base frame, a pole frame and a swivel frame is described. The FIFO communication buffer includes a FIFO memory and a FIFO control circuit. Here, a route is depicted as a linear shape, and portions of the linear shape represent portions of the route, regardless of their spatial arrangement. Pharmaceutical compositions are provided as well, as are methods of chemotherapy and chemoprevention. In each of these embodiments, the bottom surface of the membrane does not have a semiconductor substrate positioned adjacent thereto.