A method of treating estrogenic deficiencies in women while further avoiding the appearance of osteoporosis, withdrawal bleeding and cardiovascular diseases in post-menopausal women without any androgenic effect, and no deleterious effects on blood vessels comprising continuously without interruption administering to said women, a combination of 0. A user can use an application residing in the handheld device to make transactions in the local database. Also disclosed are various devices including the roller turret and methods of manufacturing these devices. The first table defines a relation between an intake air amount and a throttle opening area under a reference gauge pressure, a reference atmospheric pressure and a reference intake air temperature.