Peripherally administered Brefeldin A and its analogs and derivatives are used to enhance learning and reverse memory dysfunction through induced long term potentiation in hippocampal issues. The output of the apparatus is coupled to the gate of a switching element. The apparatus upper surface is covered with a protective member. Each clock inverter leg can further include an asymmetric variable delay circuit having an input coupled to an output of the first AOI circuit and an input coupled to a waitr_signal that can be used to delay and adjust breadth of non-overlap.