This invention relates to 6-alkynyl-pyridine of general formula their use as SMAC mimetics, pharmaceutical compositions containing them, and their use as a medicaments for the treatment andor prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. A laser pulse or beam is directed to a spatial homogenizer, which may be a plurality of lenses arranged along a plane perpendicular to the optical path of the laser energy, an example being a microlens array. The first casing has a display screen on the first surface and a window extending through the first surface and the second surface. The detection circuit detects the voltage of one terminal of the memory cell based on a first detection timing, and further, detects the voltage of one terminal of the memory cell based on a second detection timing.