A method and a system for improving operation of a hybrid vehicle are presented. The GPS module may be mounted adjacent to and work in concert with the sensor wheel. The second control part downloads the maintenance data from the maintenance-data management server to transfer the downloaded maintenance data to the first control part and transmits a maintenance result transferred from the first control part to the maintenance-data management server. The offset adder receives a value derived from the accumulator and a selected phase offset value. The methods are directed to concurrently administering a compound such as pyridoxal-5\u2032-phosphate, pyridoxamine, pyridoxal, or a 3-acylated pyridoxal analogue with a therapeutic cardiovascular compound.