The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently convert carbon dioxide and light into n-alkanes, and in particular the use of such organisms for the commercial production of n-alkanes and related molecules. Many embodiments provide a swallowable device for delivering the agents. The drill guide is provided with a first opening for receiving one drill sleeve placed in a fixed location, and a second opening having an oblong shape for receiving a second drill sleeve having an offset cannulation. or less and a viscosity at 20 C. The second extremity of the first conduit is connected to the second end of the spraying assembly. The first functional group of the modifying compound is capable of reacting with the non-self-crosslinking polymer and the second functional group is capable of crosslinking with a curing agent.