A transmitter and a method for testing the transmitter which allow easy testing for a failure in the detection processing unit thereof, thereby reducing required manpower and cost, are provided. A layer of protective material spans the gap structure to contact the first electrode and the second electrode. The edge-extended wafer translator having a central portion generally coextensive with the attached wafer, and an edge-extended portion extending beyond the boundary generally defined by the outer circumferential edge of the wafer. Specific devices are provided as are methods for manufacturing and using such devices to treat disorders of the ear, nose or throat. The non-destructive CT methods enable both extrinsic and intrinsic testing to ensure the quality of downhole components in elements such as downhole packers. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo3,4-cpyridines having therapeutic activity, which can be used in particular in oncology.