The toothbrush includes a handle portion and a brushhead assembly which comprises a head portion and a stem portion. Alternatively, a micro-controller is used to detect the polarity of the sync signals and accordingly provide a reference voltage in order to set the triggering point at the leading edge of the sync signals. The object has substantially absorbed medium in a first \u201ccool\u201d state and therefore includes a maximum weight in the first \u201ccool\u201d state due to absorption of medium. The highlow average value generator generates an average high value and an average low value of the VBI data using a plurality of window signals. , the CCR2 andor CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e. The medical devices generally comprise a needle and an over-the-needle suture lock, employed via inner and outer sheaths.