The invention describes nucleic acids encoding the Smad7 protein, including fragments and biologically functional variants thereof. In this structure, the interlayer insulating film is thicker at a corner than at a center part of the light receiver. The output from the ADC is processed digitally then a quadrature signal generator generates quadrature-related IF signals which are passed to a down-converter for conversion to baseband signals. Through the endoscope, hemostatic clipping device that is fully reversible and lockable.