The present invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formulawherein R1 to R4 are defined as in claim 1, the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV. The prosthesis can have a circumferentially expandable wall and elements that prevent the wall from collapsing once the wall is expanded. being set in a reaction zone following this reaction zone, with the proviso that the reaction temperature in the subsequent reaction zone is at least 5\xb0 C. In addition, the side enclosure frame includes an upper protrusion and a lower protrusion, formed on an inner-facing surface of the side enclosure frame. The first injection type in the combustion cycle is first deactivated in order to determine the actuator energy of said type from the second injection type. A current reduction module can be employed to offset the bias current and to reduce a portion of the bias current from appearing in a subsequent stage to the amplifier in order to mitigate power in the subsequent stage.