The present invention relates to variants of subtilisin-like proteases having decreased immunogenicity relative to their corresponding wild-type proteases. In one exemplary system for connecting a reservoir of perishable therapeutic with a lumen, a hollow hub having a first end and a second end is provided. The water pump is positioned in a portion of the skimmer box which is not vertically restricted, thus allowing multiple size water pumps to be utilized in their standard upright position without removing the mats to make room for large pumps and providing for servicing or removal of the pumps without disturbing the filter mats the filter mat holder, the dirty sump or the water inlet weir. This tree structure then can be used to reflect the ontological relationships of data stored in the columns of a database. The available host is capable of delivering IOs to the primary array controller.