A backup valve for use with a pool cleaner coupled to a source of water under pressure. One or more zones of influence each having a plurality of points of geolocational data are defined. The present invention is particularly useful in the treatment or prevention of conditions that result from low expression or activity of proteins involved in the processing of metallocorrinoids, as well as in conditions which would benefit from enhanced uptake or availability of cobalamin or its biologically active analogs of cobalamin.