The subject invention pertains to a conjugate comprising: a first region comprising the homeodomain of antennapedia or a variant thereof; and a second region not naturally associated with the first region. The rear end structure includes a first wall, a hinge plate having a plate portion disposed on an inboard side of the first wall portion and a pivot bearing sleeve extending from the plate portion through an opening of the first wall, and a nut plate disposed on an outboard side of the first wall and coupled to the hinge plate. The main feature is the H-shape profile structure of the inner tube with a slide way built with an internal diffusion slot and a perforation slot. A gear shift actuator is mounted in the gearing system for engagement or idling of the gearing system.