Human papillomavirus protein expression is downregulated in patients infected with HPV by administration of PPAR\u03b3 ligand, selective inhibitor of cyclooxygenase-2, diaryl heterocycle, inhibitor of HPV protein from a natural source andor certain non-steroidal anti-inflammatory drugs. The cover comprises a cassette-containing member, at least one chamber-defining member, and sealing means, typically sealing means that are capable of reversible attachment. The technique is also capable of accommodating generic half-slot connectors, each of which is capable of supporting a variety of data formats. The invention further provides for use of other energy sources to deliver thermal energy to tissue, for example microwave energy, Rf energy and laser energy, either in combination with ultrasound energy or independently.