An information recording method performing recording on an information recording medium having multiple rewritable recording layers each having a data area in which user data is to be recorded is disclosed. These methods may allow reducing the computational complexity of a frequency estimator while maintaining large frequency offset coverage and high frequency estimation accuracy. The flexible substrate may also have inactive regions that lie outside of the active region. The pharmaceutical combination described in this invention exhibits lower toxicity compared to that reported by the anticancer therapeutics and therefore, it represents a crucial advantage for its use in cancer therapy. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds. A power contact is electrically connected to the second layer in the first segment, and a second power contact electrically connected to the first layer in the second segment.