A molded pad for a brassiere cup contains shaved polyurethane foam inserts interleaved between thin upper and lower polyurethane foam layers. The sensor can be configured as a clamp on device, wherein the conduit walls are constructed from such an ultrasonically-matched material. With the present invention, this can be performed for both spatial beams and temporal pulses. Any fluid can be tested, for example, urine or other body fluids, environmental samples, biological samples, clinical samples, or food and beverage samples. An ion implantation process is performed to form a doped region having the first-type conductivity substantially underlying the isolation feature using at least two different implant energy. The compounds of the present invention have an excellent effect of inhibiting activated blood-coagulation factor X.