An apparatus and method for treatment of benign prostatic hyperplasia is disclosed wherein the apparatus includes an applicator having a probe having proximal and distal probe sections wherein the proximal and distal probe sections each define an axis and wherein the axes are not collinear. The promoter sequence is an isolated Oryza sativa antiquitin promoter sequence including SEQ ID NO: 1. The apparatus also includes a harrow for further mixing the soil and crop residue, and spreading the mixture evenly over the field.