Substituted spiroisobenzofuran-1,4-piperidin-3-ones and 3H-spiroisobenzofuran-1,4-piperidines capable of modulating NPY5 receptor activity are provided. The substrate has a trench formed therein. A single capture operation is performed with ancillary metadata being added to facilitate subsequent searching, indexing and format conversion. Each test failure within the remediation work order may be approved or denied. The low-pressure relief valve is provided with a second shim. The aspects include utilizing chosen rules to establish a priority for mapping, and generating mapping assignments based on the priority.