The invention provides trisubstituted pyrazoles and imidazoles of Formula I:wherein L2, q, R13, R14, R15, R16, Z1 and Z2 are as described in the Summary of the Invention; and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the peroxisome proliferator-activated receptor families, particularly the activity of PPAR\u03b4. Such devices include members configured to alter the shape of a valve annulus, reposition at least one papillary muscle, andor plug an orifice of the valve so as to provide a coaptation surface for the valve leaflets. When the voltage on the output bus drops below a first threshold, the first switch couples and thereby transfers energy from the voltage input bus to the voltage output bus and the load.