The present invention provides benzodiazepine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof. The system may comprise a computer which includes a CPU and a memory medium which is operable to store one or more programs executable by the CPU to perform the method. According to embodiments, a pump may include an ultra-high molecular weight polyethylene dynamic seal may substantially fixed relative to a cylinder wall, and a proton impregnated reciprocating plunger may pump high pressure water or a water based fluid in a system.