A controller-assisted, manually shifted transmission system having a control system and method for controlling automatic range shifts are disclosed. The apparatus comprises an elongated shaft having a means for treating urethral tissue and an expandable member deployable distal of the means for treating. The data output unit includes a first output channel and a second output channel, wherein the channels respectively generate a first output signal and a second output signal based on the data received. An ionization source generates a weakly-ionized plasma proximate to the anode and the cathode assembly. End point detection includes monitoring refractive qualities of the lens during the recontouring process, modifying the pattern through changes in the laser pulses. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation.