The invention includes a system and methods for orthogonal variable spreading factor code assignment, de-allocation and code tree pruning. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function. The liquid crystal layer is disposed in the cavity and is in direct contact with the roof layer. The nonwoven fabric also contains a plurality of microsponges on the second side of the nonwoven base, the microsponges being bound on at least two sides by the rows of stitches. An image based on the near-infrared fluorescence of the septum is displayed on the monitor and in a case where damage occurs in the septum, an image based on the near-infrared fluorescence of the core is displayed on the monitor. The first and the third sealing elements provide sealing by deformation when the closure is applied to the container.