A social media platform is provided for interacting in a three-dimensional platform. In the rotary pulser, a control circuit activates a brushless motor that rotates a windowed restrictor relative to a fixed housing to act as a shutter and window respectively. An optical element other than a light sensing element, for example a light source element, can be used in place of the or each light sensing element, with in that case the or each optical element providing light to the further optical element rather than receiving light therefrom. Using a progressive die assembly, laminas are blanked from stock sheet material and punched to form the projectiondepression. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor, where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a stable, folded protein insertion; and c) a second portion of the GPCR, where the second portion comprises the TM6 and TM7 regions of the GPCR. Related endoscopic surgical procedures are also disclosed.