The emergence of mutations in tyrosine kinases following treatment of cancer patients with molecular-targeted therapy represents a major mechanism of acquired drug resistance. The present invention is also directed to methods for storing such pharmaceutical compositions and formulations, and to the use of such pharmaceutical compositions and formulations to provide benefit to a patient in need of a pharmaceutical agent with limited aqueous solubility. According to yet another aspect, conditional processing is avoided by providing a common arithmetic operation when decoding code-words in various escape modes, but using neutral operand values in case the operation is not required. The down pipe comprises first and second channels that extend from the upper end to respective outlets. A second mask allows a second dose of phosphorus to be implanted in the sourcedrain regions.