A reflecting resin sheet provides a reflecting resin layer at the side of a light emitting diode element. The compounds are expected to be hydroxylated at the carbon atom to which X is joined, by cytochrome P450, in particular by CYP1B1, expressed at high levels in tumours. The method may also include accumulating, at the base station, signal energy received during a second portion of the transmission time interval. Alternatively, the pattern formed between the top and bottom surfaces may include a number of pitted optical fibers extending from a side of the instrument to a hidden region internal to the instrument, which does not extend to any of the sides or surfaces of the instrument. In still another embodiment, the light absorptive thin film stack is less than 200 nanometers thick.