A stacked structure is formed such that a plurality of thin plates, which include at least one liquid flow passage thin plate provided with a liquid flow passage having a predetermined pattern formed on at least one surface, are stacked with an adhesive. The adjustments to the alignment device may be made according to vertically and horizontally oriented laser lights emitted from the alignment device. 5\u2032; arranging the plurality of crystal plates in a manner such that the plane-orientation deviation, with respect to the {hkil} plane, in any given point on the major-face collective surface of the plurality of crystal plates will be not greater than 0. On the other hand, when the second supporting structure is placed above the opening, the substitute stopper is mountable on the head of the bottle in N gas atmosphere. The support elements include a downwardly arcuate notch or channel for receiving a sidewall or endwall of the platform, allowing the platform to be arranged in multiple angled orientations. In the practice of the subject invention, an anti-convulsant agent, such as topiramate, is administered to an individual.