A computer generated 3-dimensional map display includes a reference icon identifying an observation point in the geographic area defined by the map, the map being presented on a curved surface which extends from a first plane to a second plane which is substantially orthogonal to the first plane. In addition, the compounds of the present invention may be used in combination therapy with standard non-steroidal anti-inflammatory drugs and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinum, etoposide, taxol, taxotere and other alkaloids, such as vincristine, in the treatment of cancer. The material may be applied to only the center portion of the bridge to raise the film at its center but to allow the edges of the film near the sprocket holes to be free from contact with the bridge to minimize vibration. A receptor shown in SEQ ID NO: 1 is an ETA-receptor which has a high affinity for endothelins 1 and 2, especially for the endothelin 1. The one or more operations may include operating on data in a cache andor modifying entries in a memory. Only the program stream components that contain the marred video content may be recorded by a VCR or DVD recorder and the marred video is unsuitable for piracy or rebroadcast.