The disclosure provides compositions and methods for blocking the proteasome pathway, as well as compounds that block mitotic cell cycle progression. In particular, a custom conformable device consisting of an insole, or portion thereof, can serve to accommodate the unique anatomical features and characteristics of an individual wearer. The encoded image generating unit generates an encoded image. The emulsion is subsequently sulfided with a sulfiding agent, or in-situ in a heavy oil feedstock to form a slurry catalyst. A control portion controls on-off states of the first to the fourth semiconductor switching elements and performs return current circuit failure detection based on a first monitor voltage that is an electric potential of a connecting point between the first semiconductor switching element and the motor. The system is thus benign and environmentally friendly.