ET-743 is used in the preparation of a medicament for an effective treatment of a tumour by combination therapy employing ET-743 with another drug. The surgical instrumentation of the present invention includes an osteotome with a plurality of markings and a depth stop, a drill guide with jaws configured to securely engage an outer surface of the graft, and an offset guide to position the graft to the bone. The agitator wheel preferably includes agitating members for transversing a significant portion of the volume of the reservoir to contact and dislodge pulverulent material therein. The timing generator suspends the output of the column address sequence during a sample operation and resumes the output of the column address sequence at the end of the sample operation.