The system and methods describe relate to the diagnosis and quantification of abnormal limb biomechanics. A shared volume is accessed at a client computing system having a root. under the atmosphere of reducing gas, a hydrogen-stored carbonaceous material obtained by hydrogen storage in the carbonaceous material heated at more than about 50\xb0 C. The second finger event is either a finger-dragging event or a finger-up event. The methods of the invention encompass contacting the PTMs of the invention with a FVIII target pre-mRNA under conditions in which a portion of the PTM is trans-spliced to a portion of the target pre-mRNA to form a RNA molecule wherein the genetic defect in the FVIII gene has been corrected. A hood can be removably secured to the vest.