A method and apparatus for reducing latency and overhead bandwidth consumption in computer bus transactions. The timing of message notifications may be controlled in order to optimize the chances of delivering targeted content to a mobile device user based on the current geographic location of the user’s device relative to a threshold level of content consumption area. For the organic compound layer, a high molecular material having an amide group at least at one kind of side chains is used. A second communication interface is provided for outputting the relative-time timestamped data. The pump in the disposable delivery unit is activated to deliver a dose of the medicament by bringing the base unit temporarily into communication with the delivery unit. The gas ion beam from the gas ion beam irradiation device irradiates the section from a rear surface side of the sample at a specified incident angle.