The present invention is a taxidermy mannequin which includes an optional ear engagement area formed on a head portion, a lock plate which is secured to the ear engagement area, and an ear liner which is connected to the lock plate. To achieve the object, the present invention provides a cell culture patterning substrate comprising: a base material provided with a convex portion; and a cell culture region, which is a region for culturing a cell, formed on a surface of the base material, wherein the cell culture region is partitioned with the convex portion of the base material provided with the convex portion. The method includes: writing steps and to cause the variable resistance layer to change from the low resistance state to the high resistance state by applying a write voltage pulse; and an erasing step to cause the variable resistance layer to change from the high resistance state to the low resistance state. A final three dimensional CT image is reconstructed employing the motion data set. Further, the present invention provides methods for manufacturing the common ligand mimics and bi-ligands of the invention and methods for assaying the combinatorial libraries of the invention. Such methods determine relative binding sites based on thermodynamic principles, using a thermodynamic alphabet and a thermodynamic scoring matrix, with appropriate computer software, such as BLASTP.