The present invention provides methods and compositions that enable the experimental determination as to whether any gene in the genome of a diploid pathogenic organism is essential, and whether it is required for virulence or pathogenicity. An anvil weldment channel defined by spaced apart strongbacks communicates with the crusher channel and carries an adjustably positionable anvil weldment carrying two vertically spaced adjacent anvils proximate the arbor. The channel encoding includes determining the number of symbols in accordance with a payload size of the data of the first uplink signal and a total number of transmissible symbols of a Physical Uplink Shared Channel of the first uplink signal. Based on these determinations, the process is able to instruct components in the EMS to accept, redirect, refuse, modify, defer, or otherwise dispose of the connection request, the delivery attempt, or the message. The power supply is electrically coupled to the arc lamp and configured to provide power thereto, and the power control servo is coupled to the power supply, and configured to cause the power supply to provide lower power to the arc lamp at a beginning of the life span, and to provide greater power to the arc lamp toward an end of the life span. Additionally, the invention provides a method of protecting the SMN protein by administering an antioxidant.