A method, apparatus, and a system for performing an adaptive state estimation process for processing semiconductor wafers. Wherein, the first and the second resistors are electrically coupled to a first and a second low voltage differential signal input pins of the timing controller chip, respectively. More specifically, the present invention discloses methods of using recombinantly expressed andor endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The internal variable is designated in the file by a hierarchical path and is designated in the file by a hierarchical address.