There are described 11-O-substituted macrolides and their descladinose derivatives and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. The holder has a cavity and the container is received in the cavity. Next, in an effective-delay calculating step, effective-delay calculating means multiplies a delay time when the reference power-source voltage calculated by the delay calculating means is applied thereto by the delay power-source coefficient calculated by delay-power-source-coefficient determining means to determine a delay time at the operating power-source voltage. When the engine stops, the area between the roller and the roller pin is lubricated. Because the thickness of the oxide layer decreases gradually, the PN junction does not need to be located at a particular point, i. One advantage of this invention is that a lightweight, stackable tote or container may be quickly and easily manufactured in a designed size or height.