The present invention relates to novel quinoxaline, quinazoline and phthalazine derivatives as well as multimeric derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds for the treatment and prevention of brain damage resulting from brain injury, especially secondary brain damage due to traumatic brain injury. Applying a stochastic approach that reflects the history of each customer in reference to the ensemble history, the queues intercept and sort customers. A hopper module with the walls being inclined to approximately the angle of repose for the proppant is installed inside the cargo container.