The present invention discloses devices and methods relating to patterning substrates using chemical functionalization. Exemplary techniques involve correlating aspects of direct current impedance, radiofrequency conductivity, andor light measurement data obtained from the biological sample with an evaluation of immature platelet conditions in the individual. The computer determines an avatar for use in place of a video of the attendee in the video conference. In order to achieve this, the regulating element is a rotating collar which is rotationally positioned in relation to a bearing collar, and the actuating device comprises at least one mechanism which converts a linear movement into a rotational movement. The first binding specifies that the first device is allowed to access the first domain and the first binding is associated with the particular access port of the network device.