Subsystems and methods for use in patch clamp systems are provided. The design allows for replacement and retrieval of a subsea control module with a single remotely operated vehicle deployment from a vessel. 5 g of said granules is kept in a closed container having a volume of 20 ml at a temperature of 22\xb0 C. A score is assigned to the likelihood that the column corresponds to one or more predefined entities. The content may be provided over the single virtual channel in accordance with the virtual programming data.