IGF-I and insulin variants are provided that selectively bind to IGFBP-1 or IGFBP-3. The tag information and the pattern of bits surrounding the pixel to be converted to a contone value are used to reconstruct a contone image from a binary image. The sealing member 5 includes a core metal 6 provided with an elastic element 7, which is made of rubber or resin, and the IC tag 9 is held embedded in this elastic element 7.