The present invention provides compounds according to formula I and formula II and pharmaceutically acceptable salts and esters thereof, having the designations provided herein and which inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity . A vibrating plate having a peripheral projection is secured to an outside wall of the case at the peripheral projection. The flush portions are aligned along axes at the contact end. The rotary body joining tool has a small-diameter tip portion and a larger diameter portion.