Disclosed herein is a method of compensating for variations in the track pitches of optical discs. This invention also relates to treatment methods using such a composition, uses of such a composition to make medicaments, and therapeutic kits comprising such a composition. It is preferred to use a combination of native rapamycin and its tetrazole containing isomers and epimers. The order determination section executes an ideal solution calculation step, a permutation set production step and a selection order determination step to select the reception servers so as to be accessed impartially from the clients even if a reception server to be used for reception of data is increased.