Disclosed are methods and apparatus for isolating and driving a power supply or power amplifier circuit. A substrate has a first gate and a second gate. Finally, the present invention provides methods for transplanting cells and engineering tissue using the fibrin microbeads of the present invention. The fuel injection pump is arranged on one horizontal side of the cylinder block and a belt tensioner of the belt transmission device is disposed in front of the fuel injection pump. The transparent substrate positioned at the upper side and the substrate positioned at the lower side are arranged parallel to each other with alignment films provided on the transparent electrode and on the metallic reflective electrode facing each other. The light emitting diode package comprises a submount substrate which includes a mounting region having side walls inclined upwardly, first and second cavities formed around the mounting region, and first and second grooves extending between the mounting region and the first and second cavities on an upper surface of the submount.