Targeted therapeutic agents, comprising a linking carrier, a therapeutic entity associated with the linking carrier, and at least one targeting entity are provided, as well as methods for their preparation and use. Preferred prostheses exhibit reduced production of particles from the prosthesis during wear of the prosthesis, and are substantially oxidation resistant. The sheet also comprises run-out perforation lines extending from the periphery to edges of the sheet, wherein the sheet can be folded along the run-out perforations to detach the object from the sheet. An arithmetic decoder recovers the target block by decoding the encoded data using the selected statistical model. A lateral opening extends through the cap in a direction substantially perpendicular to the longitudinal axis and is alignable with the gap. A plurality of substrates are connected in serial flow but axially offset relationship to obtain improved performance.