2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes. First, an analyte protein is subjected to PMF analysis, and the gene of the protein is identified. The turbine pressure is maintained substantially equal to compressor pressure by a EGR bypass between the intake and exhaust manifold.